PANCREATIC FIBROSIS IN PATIENTS WITH ALCOHOLIC DEPENDENCE SYNDROME

Pancreatic fibrosis in patients with alcoholic dependence syndrome was studied histopathologically. In 30 of 41 autopsied patients with alco holic dependence syndrome, fibrosis was observed despite the absence o f clinical pancreatitis. The fibrosis was categorized into three types , according to Martin's classification: intralobular sclerosis in 15 c ases, perilobular sclerosis in seven cases, and a mixed intralobular a nd perilobular sclerosis in the remaining eight cases. The type of the fibrosis was not related to the duration of alcohol abuse. Alcoholic liver cirrhosis was coexistent in 23 of the 30 cases of pancreatic fib rosis. These cases were also divided into categories according to the three types, as follows: intralobular sclerosis in 12 (80%) of 15 case s, perilobular sclerosis in four (57%) of seven cases, and mixed scler osis in seven (88%) of eight cases. That is, intralobular and mixed sc lerosis were frequently coexistent with alcoholic liver cirrhosis. Whe n the pancreases from the 19 subjects with intralobular sclerosis and mixed sclerosis coexistent with liver cirrhosis in alcoholic dependenc e syndrome were compared with 20 pancreases from patients with nonalco holic liver cirrhosis, periacinar (or intralobular) fibrosis was found in all cases of the former, but in none of the latter. Hence, it was concluded that periacinar fibrosis occurred as a result of alcohol abu se. Pancreatic fibrosis in patients with alcoholic dependence syndrome was distributed mainly in the intralobular areas and was frequently c oexistent with alcoholic liver cirrhosis.