We retrospectively reviewed the effects of intravenous gamma-globulin
(IVGG) re-treatment of 13 children with Kawasaki disease and persisten
t or recrudescent fever. Fever and mucocutaneous inflammation resolved
within 48 hours in nine patients; fever abated in two other children
after a third course of IVGG. We conclude that IVGG re-treatment of Ka
wasaki disease appears to be safe and may improve the clinical course.