A MODELING STUDY OF SOLUTE REABSORPTION ALONG RAT PROXIMAL TUBULE

We present a model of steady state solute and water reabsorption along the rat proximal tubule. Major co- and counter-transport systems in t he apical and basolateral cell membranes are described using kinetic d escriptions based on data from the flows and solute concentrations alo ng the length of the proximal tubule as a function of filtration rate and peritubular solute concentrations. We show that for many aspects o f proximal tubule transport physiology this kinetics-based model is an adequate representation of the mammalian proximal tubule.