PHAGOCYTIC-ACTIVITY IN STRESSED MICE - EFFECTS OF ALPRAZOLAM

Authors
FREIREGARABAL M NUNEZ MJ FERNANDEZRIAL JC COUCEIRO J GARCIAVALLEJO L REYMENDEZ M
Citation
M. Freiregarabal et al., PHAGOCYTIC-ACTIVITY IN STRESSED MICE - EFFECTS OF ALPRAZOLAM, Research in immunology, 144(5), 1993, pp. 311-316
Citations number
26
Categorie Soggetti
Immunology
Journal title
Research in immunology → ACNP
ISSN journal
09232494
Volume
144
Issue
5
Year of publication
1993
Pages
311 - 316
Database
ISI
SICI code
0923-2494(1993)144:5<311:PISM-E>2.0.ZU;2-P
Abstract
Mice exposed to a chronic auditory stressor and daily injected with al prazolam (1 mg/kg/day, s.c.) showed a reduction in stress-induced supp ression of the in vitro and in vivo activity of phagocytosis, measured using the zymosan particle uptake method and the carbon clearance tes t, respectively. Pretreatment with Ro-15-1788 (10 mg/kg, s.c.), a cent ral nervous system benzodiazepine antagonist, resulted in suppression of the effects of alprazolam in stressed mice.