Rs. Mazze, TREATMENT OF GLUCOSE-INTOLERANCE IN PREGNANCY - STAGED DIABETES MANAGEMENT, International journal of clinical pharmacology, therapy and toxicology, 31(10), 1993, pp. 497-505
Current methods for the treatment of glucose intolerance first discove
red in pregnancy are reviewed and a systematic data-based approach is
introduced. Gestational diabetes mellitus (GDM) is a leading cause of
adverse perinatal outcome in 5% of all pregnancies in the United State
s. Early detection and initiation of treatment meant to restore euglyc
emia will prevent many of the major complications associated with hype
rglycemia. Staged Diabetes Management (SDM) is introduced in this pape
r as an innovative approach for the detection and treatment of GDM and
glucose intolerance in pregnancy. Relying on self-monitored blood glu
cose data, SDM guides the primary care physician through increasingly
more complex regimens until euglycemia is reached. Computer-based tech
nologies assist the clinical decision-making by producing Ambulatory G
lucose Profiles (AGP), which are graphic representations of glycemic c
ontrol. SDM combined with AGP technology are meant to significantly re
duce the threefold greater risk of adverse outcome in pregnancy experi
enced by women with GDM.