EFFECT OF HOT-WATER EXTRACT OF CHLORELLA-VULGARIS ON CYTOKINE EXPRESSION PATTERNS IN MICE WITH MURINE ACQUIRED-IMMUNODEFICIENCY-SYNDROME AFTER INFECTION WITH LISTERIA-MONOCYTOGENES

We have previously reported that oral administration of hot water extr act of Chlorella vulgaris (CVE) enhances resistance to Listeria monocy togenes through augmentation of Listeria-specific cell-mediated immuni ty in normal mice and mice with murine acquired immunodeficiency syndr ome (MAIDS) caused by murine leukemia virus (MuLV) LP-BM5. To elucidat e the mechanisms whereby CVE augments the cell-mediated immunity, we e xamined the expression patterns of mRNA for cytokines in normal and MA IDS mice given CVE orally after L. monocytogenes infection. The expres sion levels of IL-1 alpha, IL-12, GM-CSF, MIP and TNF alpha genes were significantly augmented in the peritoneal adherent cells by oral.