METASTATIC BONE-TUMORS - NONSURGICAL TREATMENT - OUTCOME AND SURVIVAL

Of 683 (16.1%) consecutive patients investigated from October 1984 to December 1985, 110 had various malignant tumors and secondary bone inv olvement. In 82 of 110 patients (74.5%), the primary tumor was located in the breast, and the percentage of clinical and radiographic object ive responses (OR) of their bone lesions (42.7% and 22.8%, respectivel y) was higher than for cancer in other sites (clinical OR, 21.4%; radi ographic OR, 15.8%). The average survival time of 82 breast cancer pat ients was 87.4 months, or 38 months from the diagnosis of the bone met astases. Of the 110 patients with bone metastases, 60 patients (54.5%) had secondary spinal involvement. The clinical and radiographic OR (3 8.4% and 30.2%) were better in the patients with vertebral metastases than in the patients with bone metastases in other sites (clinical OR, 36%; radiographic OR, 9.1%). The average survival time of the patient s with vertebral involvement was 99.4 months, or 40.4 months from the time of diagnosis of the bone metastases. From the results obtained, i n terms of OR and survival for patients with bone metastases, early an d aggressive treatment should be considered to improve the patients' l ife quality.