Mrw. Ulbig et al., MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE-II ASSOCIATED WITH CENTRAL SEROUS RETINOPATHY, American journal of ophthalmology, 116(4), 1993, pp. 410-413
Membranoproliferative glomerulonephritis type II is specifically assoc
iated with the presence of dense deposits in the basement membrane of
Bruch's membrane, which result in lesions similar to basal laminar dru
sen, exudative drusen, and retinal pigment epithelial detachments. In
advanced stages of this dense-deposit retinopathy, choroidal neovascul
arization may occur. We observed a 36-year-old patient with membranopr
oliferative glomerulonephritis type II who developed central serous re
tinopathy in the presence of specific dense-deposit-associated fundus
lesions. The diffuse drusenlike dense deposits (at the level of Bruch'
s membrane) and associated retinal pigment epithelial detachments appe
ar to contribute to the pathogenesis of central serous retinopathy. Th
us changes in Bruch's membrane may be involved in the development of c
entral serous retinopathy.