MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS TYPE-II ASSOCIATED WITH CENTRAL SEROUS RETINOPATHY

Membranoproliferative glomerulonephritis type II is specifically assoc iated with the presence of dense deposits in the basement membrane of Bruch's membrane, which result in lesions similar to basal laminar dru sen, exudative drusen, and retinal pigment epithelial detachments. In advanced stages of this dense-deposit retinopathy, choroidal neovascul arization may occur. We observed a 36-year-old patient with membranopr oliferative glomerulonephritis type II who developed central serous re tinopathy in the presence of specific dense-deposit-associated fundus lesions. The diffuse drusenlike dense deposits (at the level of Bruch' s membrane) and associated retinal pigment epithelial detachments appe ar to contribute to the pathogenesis of central serous retinopathy. Th us changes in Bruch's membrane may be involved in the development of c entral serous retinopathy.