N. Fuchsberger et al., IN-VITRO ANTIPROLIFERATIVE EFFECT OF INTERFERON-ALPHA IN SOLID TUMORS- A POTENTIAL PREDICTIVE TEST, Neoplasma, 40(5), 1993, pp. 293-296
An in vitro test for the antiproliferative effect of human leukocyte I
nterferon (IFN-alpha) was performed in primary cultures of tumor cells
obtained from 32 patients with either malignant melanoma (13), renal
carcinoma (4) or bladder carcinoma (15). Our results demonstrated acti
vity of IFN in all three groups of solid tumors. However, appreciable
differences in sensitivity to antiproliferative effect of IFN between
individual tumors of the same type were found. The potential of this a
ntiproliferative test for prediction of treatment response in IFN-ther
apy is discussed.