CHANGES OF THE CU AND ZN CONTENTS IN LUNG AND LIVER IN INTESTINAL ISCHEMIC REPERFUSION AND GENERAL ISCHEMIC REPERFUSION IN RABBITS

The changes of pulmonary and liver Cu-Zn contents were determined and evaluated in intestinal ischemic reperfusion (IIR) and general ischemi c reperfusion (GIR) of rabbits. The contents of pulmonary Zn and liver Cu were found to be lower, and Cu/Zn ratio increased in lung tissue a nd decreased in liver tissue in IIR. The contents of pulmonary Zn were increased, and the contents of liver Cu were decreased; Cu/Zn ratio a lso decreased in both tissues in GIR. Pulmonary Cu and liver Zn conten ts were not changed in IIR and GIR. These results showed that lower or higher Zn in lung tissue and lower Cu in liver tissue were related to the acute tissue injury during IIR and GIR, suggesting that regulatin g the state of pulmonary Zn and liver Cu should be attempted during th e prevention and treatment of both ischemic reperfusions.