HUMAN IMMUNE-RESPONSE TO POLYDIMETHYLSILOXANE (SILICONE) - SCREENING STUDIES IN A BREAST IMPLANT POPULATION

Citation
Le. Wolf et al., HUMAN IMMUNE-RESPONSE TO POLYDIMETHYLSILOXANE (SILICONE) - SCREENING STUDIES IN A BREAST IMPLANT POPULATION, The FASEB journal, 7(13), 1993, pp. 1265-1268
Citations number
8
Categorie Soggetti
Biology,Biology
Journal title
ISSN journal
08926638
Volume
7
Issue
13
Year of publication
1993
Pages
1265 - 1268
Database
ISI
SICI code
0892-6638(1993)7:13<1265:HITP(->2.0.ZU;2-F
Abstract
Although initially it was thought that polydimethylsiloxane (silicone) was biologically inert, recent published studies have demonstrated va rying levels of IgG antibody reactive with this structure in humans. T he objective of our study was to determine whether silicone implanted in humans results in a measurable immune response directed against a 3 700 mol wt hydroxyl terminated silicone molecule and whether that resp onse could be correlated with the level of presumed silicone exposure as inferred by clinical history. In a blind study, sera from 111 patie nts, with and without breast implants, were sent to a laboratory using an enzyme-linked immunosorbent assay to determine specific anti-silic one IgG antibody levels. Test results showed that patients with implan ts demonstrated statistically significant elevation in anti-silicone a ntibodies compared with the unimplanted control, groups. The highest a nti-silicone antibody levels were measured in implanted women with eit her frank implant ruptures or leakage of their silicone gel implants.