Hu. Demuth et al., INHIBITION OF AMINOPEPTIDASES BY N-AMINOACYL-O-4-NITROBENZOYL HYDROXAMATES, Biochimica et biophysica acta, 1202(2), 1993, pp. 265-270
10 N-aminoacyl-O-4-nitrobenzoyl hydroxamates were investigated as pote
ntial inhibitors of aminopeptidases. While the metal-depending enzymes
aminopeptidase M, aminopeptidase P and leucine aminopeptidase were in
hibited reversibly by the compounds, the thiol enzyme cathepsin H was
inhibited efficently in time-dependent reactions according to its subs
trate specificity. N-phenylalanyl-O-4-nitrobenzoyl hydroxamate was sho
wn to be most effective, exhibiting a second-order-rate constant of in
hibitition of 31 766 M-1 s-1.