ELEVATED PLASMA INTERLEUKIN-6 - A BIOCHEMICAL MARKER OF HUMAN PRETERMLABOR

Citation
N. Laham et al., ELEVATED PLASMA INTERLEUKIN-6 - A BIOCHEMICAL MARKER OF HUMAN PRETERMLABOR, Gynecologic and obstetric investigation, 36(3), 1993, pp. 145-147
Citations number
8
Categorie Soggetti
Obsetric & Gynecology
ISSN journal
03787346
Volume
36
Issue
3
Year of publication
1993
Pages
145 - 147
Database
ISI
SICI code
0378-7346(1993)36:3<145:EPI-AB>2.0.ZU;2-D
Abstract
Maternal peripheral venous plasma interleukin 6 (IL-6) concentrations were determined during human pregnancy and labour at term and preterm. During preterm labour, IL-6 concentrations were significantly elevate d (p < 0.02) compared to gestationally matched, non-labouring controls (53.7 +/- 15.7 pg/ml, n = 17, and 15.4 +/- 6.4 pg/ml, n = 23, respect ively). IL-6 concentrations did not vary significantly during normal p regnancy and labour at term. These data support a role for IL-6 in the pathogenesis of human preterm labour, are evidence for the contention that preterm labour is mechanistically distinct at a biochemical leve l from normal labour at term and identify maternal peripheral venous p lasma IL-6 as a biochemical marker of this condition.