DISPOSITION AND RESPIRATORY EFFECTS OF INTRATHECAL MORPHINE IN CHILDREN

Background: The extent and duration of respiratory depression after op ioid administration are poorly defined in infants and children. Method s: The disposition and respiratory effects of intrathecal morphine wer e studied in ten patients (ages 4 months-15 yr) after repair of cranio facial defects. Morphine, 0.02 mg/kg, was administered intrathecally b efore the end of surgery. Postoperatively, we determined the minute ve ntilation (V(E)) in response to increasing partial pressure of end-tid al carbon dioxide (PET(CO2)) during carbon dioxide rebreathing. The sl ope (V(E)/PET(CO2)) and intercept (V(E) at PET(CO2), 60 mmHg, V(E) 60) of the carbon dioxide response curve were calculated at 6, 12, and 18 h after morphine administration. Cerebrospinal fluid (CSF) Results: M ean V(E)/PET(CO2), decreased from a preoperative value of 35.1 +/- 3.7 to 16.3 +/- 2.8 ml . kg-1 . min-1 . mmHg-1 at 6 h after morphine, and remained depressed to 23.4 +/- 2.9 and 23.5 +/- 3.3 ml . kg-1 . min-1 . mmHg-1 at 12 h and 18 h, respectively, compared to preoperatively). The infants' (n = 3) V(E)/PET(CO2) at 6 h were 21, 4, and 27 ml . kg- 1 . min-1 . mmHg-1. Mean V(E) 60 decreased from 874 +/- 125 to 276 +/- 32 ml . kg-1 . min-1 at 6 h, but then recovered at 12 and 18 h to 491 +/- 68 and 567 +/- 82 ml . kg-1 . min-1, respectively. The infants' V (E) 60 at 6 h were 350, 12, and 245 ml . kg-1 . min-1. Mean CSF morphi ne concentration was 2,860 +/- 540 ng/ml at 6 h, and decreased to 640 +/- 220 and 220 +/- 150 ng/ml at 12 and 18 h, respectively. Conclusion s: intrathecal morphine, 0.02 mg/kg, depressed the ventilatory respons e to carbon dioxide for up to 18 h concomitant with increased CSF morp hine concentrations. Infants (4-12 months of age) did not exhibit grea ter ventilatory depression than did children (2-15 yr of age).