EFFECT OF DIETHYLNITROSAMINE ON PROSTAGLANDIN-E AND LIPID-PEROXIDATION LEVELS IN RATS LIVER, LUNG AND RENAL TISSUE

We have investigated the generation of a prooxidant state and effect o n prostaglandin E (PGE) levels after administration of diethylnitrosam ine (DENA) to rats. Lipid peroxides were assayed by monitoring thiobar bituric acid (TBA) a reactive material. PGE - like activity was assaye d by using bioassay procedure. Our results demonstrate that increased lipid peroxide and decreased PGE levels were found in a dose dependent manner in DENA injected groups when compared to control groups. Accor ding to these findings, it is suggested that there is a negative corre lation between carcinogenic DENA induced lipid peroxidation and PGE in rat's liver, lung, and renal tissue.