SUCCESSFUL TREATMENT OF ANTIMONY-RESISTANT VISCERAL LEISHMANIASIS WITH LIPOSOMAL AMPHOTERICIN-B IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

We describe two cases of visceral leishmaniasis in patients infected w ith human immunodeficiency virus (HIV); both cases were resistant to a ntimony compounds but were cured with liposomal amphotericin B, with n o significant toxicity. A review of the previous reported cases of ant imony-resistant visceral leishmaniasis in HIV-infected patients confir med the effectiveness of treatment with liposomal amphotericin B, whic h directly targets infected macrophages and reaches high levels in pla sma and tissue.