CUTANEOUS CRYPTOCOCCOSIS IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA RECEIVING THERAPY WITH PHOTOPHERESIS AND METHOTREXATE

Photopheresis is being used with increasing frequency as therapy for p atients with neoplastic and dermatologic diseases and is being evaluat ed as therapy for patients with AIDS. We describe a patient with advan ced cutaneous T cell lymphoma who developed pulmonary and cutaneous cr yptococcosis after receiving therapy with photopheresis and biweekly m ethotrexate. We consider the potential roles of cutaneous T cell lymph oma, methotrexate, and photopheresis as predisposing factors in the de velopment of serious cryptococcal infections.