In Pakistan there are a number of acute problems related to maternal a
nd infant health in the perinatal period. There is also lack of reliab
le data needed for the formulation of action strategies. To provide a
database 1490 women have been followed from the 5th month of pregnancy
in four different areas at various levels of urbanization and socio-e
conomic development. After adjusting for gestational age, the proporti
on of newborns with weight for length < -2SDS in relation to the Swedi
sh National Standard was 12-31 % for boys and 12-25 % for girls, the f
igure being highest in the most deprived area. Preterm birth was infre
quent compared with IUGR. The overall prevalence rate of birth defects
was 21 % out of which 8 % were severe defects. The overall perinatal
mortality rate was 56/1000 births, with rates of 60, 75, 36 and 33/100
0 births for the village, periurban slum, urban slum and the upper mid
dle class. Two thirds of the deaths were related to either a continuat
ion of intrauterine disturbances or severe congenital defects incompat
ible with life. One third of the deaths were due to infection; mostly
diarrhoea, clinical sepsis and ARI. Neonatal mortality was significant
ly related to birth length ( < -2SDS, odds ratio 5.5) and length of ge
station ( < 37 weeks, odds ratio 5.6) and was to a lesser extent relat
ed to weight (< -2SDS, odds ratio 2.0) and weight for length (< -2SDS,
odds ratio 1.3). Forty percent of the mothers had weight for height b
elow -2SDS, 23-35 % had height < -2SDS. Forty percent of mothers from
a subset within the cohort had a hemoglobin < 10 gm/dl and 20 % showed
signs of pre-eclampsia. This presentation raises the issue of expandi
ng the current Child Survival Programs into the perinatal period as we
ll.