Human donor sclera is commonly used in glaucoma surgery with a tube-sh
unt (eg, Molteno, Baerveldt, Shocket, Krupin-Denver) to cover the exte
rnal portion of the silicone tube and prevent its erosion through the
overlying conjunctiva. Common problems with this technique include imm
une-mediated melting of the graft and the potential for infectious dis
ease transmission by the grafted material. A case is presented of a pa
tient in whom a low-grade iridocyclitis was associated with the gradua
l melting of a scleral patch graft; the scleral patch was then replace
d with commercially available, dehydrated human dura mater. The practi
cal and theoretical advantages of cadaveric human dura mater in tube-s
hunt glaucoma surgery are discussed.