CHIRAL SEPARATION OF BASIC DRUGS USING CYCLODEXTRINS AS CHIRAL PSEUDO-STATIONARY PHASES IN CAPILLARY ELECTROPHORESIS

Capillary electrophoresis was used for the chiral resolution of basic racemic drugs in general and in particular for dimethindene and four p ossible metabolites. Conditions for optimum enantioselectivity and res olution were determined by changing the cyclodextrin type, cyclodextri n concentration, pH of the run buffer, applied current and capillary t emperature.