Since the isolation of the first yeast protein phosphatase genes in 19
89, much progress has been made in understanding this important group
of proteins. Yeast contain genes encoding all the major types of prote
in phosphatase found in higher eukaryotes and the ability to use power
ful genetic approaches will complement the wealth of biochemical infor
mation available from other systems. This review will summarize recent
progress in understanding the structure, function and regulation of t
he PPP family of protein serine-threonine phosphatases, concentrating
on the budding yeast Saccharomyces cerevisiae.