NO EVIDENCE FOR AN ALLELIC ASSOCIATION BETWEEN SCHIZOPHRENIA AND MARKERS D22S278 AND D22S283

Authors
WILLIAMS NM JONES LA MURPHY KC CARDNO AG ASHERSON P WILLIAMS J MCGUFFIN P OWEN MJ
Citation
Nm. Williams et al., NO EVIDENCE FOR AN ALLELIC ASSOCIATION BETWEEN SCHIZOPHRENIA AND MARKERS D22S278 AND D22S283, American journal of medical genetics, 74(1), 1997, pp. 37-39
Citations number
13
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of medical genetics → ACNP
ISSN journal
01487299
Volume
74
Issue
1
Year of publication
1997
Pages
37 - 39
Database
ISI
SICI code
0148-7299(1997)74:1<37:NEFAAA>2.0.ZU;2-I
Abstract
We report a case control association study using markers D22S278 and D 22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 con trols matched for ethnicity, age and sex. No differences between allel e frequencies for either marker were observed when the two groups were compared (D22S278: chi(2) = 6.53, df = 7, P = 0.51; D22S283: chi(2) 1 4.73, df = 15, P = 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia. (C) 1997 Wiley-Liss, In c.