SYNTHESIS OF SULFATED DERIVATIVES OF CURDLAN AND THEIR ANTI-HIV ACTIVITY

Sulfopropyl curdlan was synthesized, its structure was determined, and the anti-HIV activity was compared with that of standard curdlan sulf ates obtained with piperidine N-sulfonic acid in dimethyl sulfoxide. I t was shown that sulfopropyl curdlan exhibits weaker anti-HIV activity than curdlan sulfate. Curdlan sulfates were synthesized with a SO3-py ridine complex in a heterogeneous phase. It was shown from C-13-NMR sp ectra of acetylated curdlan sulfates that they had a different substit uent distribution from standard curdlan sulfate. The cytotoxicity of t he curdlan sulfates was attributed to their heterogeneous structure.