ELECTROPHYSIOLOGICAL AND IMMUNOGENETIC FINDINGS IN RECURRENT MONOSYMPTOMATIC-TYPE HYPERSOMNIA - A STUDY OF 2 UNRELATED ITALIAN CASES

MSLT and immunogenetic findings in two unrelated Italian subjects with recurrent monosymptomatic hypersomnia are reported. In both patients MSLT documented a markedly increased daytime sleep propensity during t he attacks without augmented REM sleep pressure. Both patients share t he same HLA haplotype (HLA-DR1, DQ1) which has been found in Kleine-Le vin syndrome. This makes these subtypes of recurrent hypersomnia indis tinguishable one from the other, under the immunogenetic profile, but permits differentiation from narcolepsy which is HLA-DR2, DQ1 closely linked.