LUMINOIMMUNOMETRIC ASSAY OF TISSUE POLYPEPTIDE ANTIGEN (TPA) AND CANCER ANTIGEN-125 (CA-125) IN BREAST-CANCER PATIENTS

Authors
ELAHMADY O HALIM AB EISSA S
Citation
O. Elahmady et al., LUMINOIMMUNOMETRIC ASSAY OF TISSUE POLYPEPTIDE ANTIGEN (TPA) AND CANCER ANTIGEN-125 (CA-125) IN BREAST-CANCER PATIENTS, Disease markers, 11(2-3), 1993, pp. 83-90
Citations number
26
Categorie Soggetti
Genetics & Heredity",Pathology
Journal title
Disease markers → ACNP
ISSN journal
02780240
Volume
11
Issue
2-3
Year of publication
1993
Pages
83 - 90
Database
ISI
SICI code
0278-0240(1993)11:2-3<83:LAOTPA>2.0.ZU;2-E
Abstract
Serum TPA and CA- 1 25 were determined in 86 individuals (66 with brea st cancer representing the different stages and grades of the disease and 20 normal healthy controls). TPA and CA-125 were estimated using t he LIA reagents supplied by BYK Sangtec. TPA showed sensitivity rates of 31.8%, 42.4% and 51.5% while CA- 125 showed sensitivities of 16.3%, 18.6% and 25.6% at specificity levels of 100%, 95% and 90% respective ly. Combined determination of the two markers resulted in some improve ment in sensitivity. For follow-up of breast cancer patients after sur gery both markers were of value and showed near-identical patterns.