INTERLEUKIN-7, A MAJOR T-LYMPHOCYTE CYTOKINE

Authors
COSTELLO R IMBERT J OLIVE D
Citation
R. Costello et al., INTERLEUKIN-7, A MAJOR T-LYMPHOCYTE CYTOKINE, European cytokine network, 4(4), 1993, pp. 253-262
Citations number
92
Categorie Soggetti
Cytology & Histology
Journal title
European cytokine network → ACNP
ISSN journal
11485493
Volume
4
Issue
4
Year of publication
1993
Pages
253 - 262
Database
ISI
SICI code
1148-5493(1993)4:4<253:IAMTC>2.0.ZU;2-Q
Abstract
IL-7 is a single-chain 25 kDa protein first identified in bone marrow cultures through its pre-B cell growth factor properties, then also de scribed as a potent T-lymphocyte growth factor. This review relates to the molecular and functional aspects of interleukin-7 (IL-7) and its receptor (IL-7R). We focused on the role of IL-7 in T-cell activation, cytotoxicity generation, leukemic cell growth and immunotherapy.