E. Rondeau et al., EFFECT OF PROPHYLACTIC GANCICLOVIR ON CYTOMEGALOVIRUS-INFECTION IN RENAL-TRANSPLANT RECIPIENTS, Nephrology, dialysis, transplantation, 8(9), 1993, pp. 858-862
Cytomegalovirus (CMV) infection is the most frequent infectious compli
cation observed in renal transplant recipients and induces a significa
nt morbidity in these patients due to CMV disease itself and to associ
ated renal dysfunction or opportunistic superinfection. In order to ev
aluate the effect of ganciclovir prophylaxis we conducted an open-labe
l prospective randomized study of ganciclovir administration in CMV se
ronegative recipients of a renal allograft from CMV seropositive donor
s. Ganciclovir (5 mg/kg b.i.d./day for 14 days) was started on day 14
after transplantation. Thirty-two patients were included in this study
(I 5 in the control group, 17 in the ganciclovir group). There was no
significant difference between the two groups for age, immunosuppress
ive regimen, number of rejection, steroid pulses, and OKT3 treatments.
Renal and patient outcomes were similar in both groups. The rate of C
MV infection and CMV disease were similar in both groups (80% and 73.3
% in the control group versus 70.6% and 47.1% in the ganciclovir group
; P=NS). Less severe CMV disease was observed in the ganciclovir group
compared to controls. The delay between transplantation and CMV infec
tion was significantly longer in the ganciclovir group compared to con
trol group (68.1 +/- 5.1 versus 44.0 +/- 5.2 days, P < 0.005). Twelve
control patients (80%) versus nine (53%) of the ganciclovir group requ
ired curative treatment with ganciclovir after the diagnosis of CMV in
fection (NS). All the patients recovered from CMV disease and no signi
ficant side-effect was observed during ganciclovir administration. We
conclude that prophylactic ganciclovir administration from day 14 to d
ay 28 after transplantation does not prevent CMV infection in seronega
tive recipients of renal allograft from seropositive donors but prolon
gs the incubation period. Longer prophylaxis by ganciclovir in these p
atients should be tested.