IMMUNOCYTOCHEMICAL EVIDENCE FOR ASSOCIATION OF SY38 WITH NEUROTUBULESIN THE RAT-BRAIN

Authors
GAJKOWSKA B VIRON A
Citation
B. Gajkowska et A. Viron, IMMUNOCYTOCHEMICAL EVIDENCE FOR ASSOCIATION OF SY38 WITH NEUROTUBULESIN THE RAT-BRAIN, Neuro endocrinology letters, 15(5-6), 1993, pp. 437-441
Citations number
8
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
15
Issue
5-6
Year of publication
1993
Pages
437 - 441
Database
ISI
SICI code
0172-780X(1993)15:5-6<437:IEFAOS>2.0.ZU;2-P
Abstract
Synaptophysin distribution in CA1 region of hippocampus, hypothalamus and neurohyPoPhysis of the rats was investigated immunocytochemically using monoclonal antibody SY38. Thin sections of tissues were labelled with SY38 followed by a secondary goat anti-rat IgG coupled to 10nm c olloidal gold particles. Immunostaining showed the presence of synapto physin in the region of Golgi complex in the neurons of hypothalamus, on the microvesicles of neurohypophysis, on the typical synaptic vesic les in all the nerve endings, on the small vesicles of agranular axona l reticulum closely associated with neurotubules, and on some neurotub ules in hippocampus and hypothalamus. The data support the hypothesis that synaptophysin has a prominent role in the interaction with neurot ubules.