SPANTIDE-III, A SUPERIOR TACHYKININ ANTAGONIST WITH HIGH POTENCY AND NEGLIGIBLE NEUROTOXICITY

Authors
FOLKERS K HAKANSON R FENG DM XU JC JANECKA A WANG ZY
Citation
K. Folkers et al., SPANTIDE-III, A SUPERIOR TACHYKININ ANTAGONIST WITH HIGH POTENCY AND NEGLIGIBLE NEUROTOXICITY, Amino acids, 5(2), 1993, pp. 233-238
Citations number
17
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
5
Issue
2
Year of publication
1993
Pages
233 - 238
Database
ISI
SICI code
0939-4451(1993)5:2<233:SASTAW>2.0.ZU;2-7
Abstract
Five new antagonists of Substance P were designed and synthesized towa rd increasing potency and safety. One of them was more effective than Spantide II, which was the basis for the design. It was named Spantide III and has the structure: cLys,Pro,Pal,Pro,D-Cl2Phe,Asn,D-Trp,Phe,D- Pal,Leu, NleNH2.