CONTROL OF BREAST-CANCER CELL-GROWTH BY STEROIDS AND GROWTH-FACTORS -INTERACTIONS AND MECHANISMS

Over the past two decades, the simple model for control of breast canc er growth involving one or two factors acting directly or indirectly v ia endocrine pathways has turned into a complex model implicating nume rous interacting factors and the diverse cell populations constituting breast tumors. Current approaches to breast cancer therapy now requir e integration of these multiple parameters and enhanced understanding of the different levels of their intricate interactions.