ANTIBACTERIAL ACTIVITY OF TEPRENONE, A NONWATER-SOLUBLE ANTIULCER AGENT, AGAINST HELICOBACTER-PYLORI

Teprenone, a non water-soluble antiulcer agent, is a derivative of ter pene. The antibacterial activity of teprenone against Helicobacter pyl ori was examined by the disc method and survival test in albumin broth including teprenone. Growth of H. pylori around the disc charged with teprenone was inhibited on Brucella agar supplemented with bovine ser um albumin fraction V, charcoal, or beta-cylodextrin, but not with blo od or egg yolk emulsion. Furthermore, when H. pylori was exposed in br oth including teprenone, H. pylori did not survive after 20 hours at 0 .25 approximately 10 ppm. These results indicate that teprenone has an tibacterial activity against H. pylori.