Recent evidence suggests that in addition to altering energy balance,
neuropeptide Y (NPY) may stimulate ingestive behavior by modifying the
orosensory quality of ingested substances. The present experiments in
vestigated the effect of intracerebroventricular administration of NPY
(5 mug/5 mul) on ingestion of various flavored solutions in nondepriv
ed rats. Experiment 1 examined the effects of NPY on ingestion of a ra
nge of concentrations of saline, sucrose, and saccharin solutions in s
ingle-bottle tests. Results indicated that NPY stimulates ingestion of
both sucrose and saccharin solutions that are normally palatable, In
Experiment 2, palatable sucrose solutions flavored with either orange
or black cherry Kool-Aid for separate training groups were selectively
associated with NPY injection during single-bottle training sessions.
Subsequent two-bottle preference tests showed a significant shift in
preference toward the flavor paired with NPY during training. The resu
lts of these experiments extend previous findings by showing that NPY
can stimulate ingestion of sweet solutions regardless of caloric value
and may potentiate sweet taste preference via an associative mechanis
m.