BIOTRANSFORMATION OF ALKENES BY HALOPEROXIDASES - REGIOSPECIFIC BROMOHYDRIN FORMATION FROM CINNAMYL SUBSTRATES

Authors
COUGHLIN P ROBERTS S RUSH C WILLETTS A
Citation
P. Coughlin et al., BIOTRANSFORMATION OF ALKENES BY HALOPEROXIDASES - REGIOSPECIFIC BROMOHYDRIN FORMATION FROM CINNAMYL SUBSTRATES, Biotechnology letters, 15(9), 1993, pp. 907-912
Citations number
11
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
15
Issue
9
Year of publication
1993
Pages
907 - 912
Database
ISI
SICI code
0141-5492(1993)15:9<907:BOABH->2.0.ZU;2-A
Abstract
A study of bromohydrin formation from some cinnamyl substrates by the heme-dependent chloroperoxidase from Caldariomyces fumago has identifi ed differences in the regio- and diastereospecificity of this enzyme r elative to chemical hydrobromination. Diastereospecificity of bromohyd rin formation from (E)-4-phenyl-buten-2-ol by the vanadium-dependent b romoperoxidase from the alga Corallina officinalis is similar to that of the fungal enzyme but significantly different to the equivalent che mical reaction.