A CASE OF ANTINUCLEAR ANTIBODY NEGATIVE SYSTEMIC LUPUS-ERYTHEMATOSUS ASSOCIATED WITH PENILE ULCER

We report here an old male patient with anti-nuclear antibody (ANA) ne gative systemic lupus erythematosus (SLE) with active renal disease an d penile ulcer. He revealed nephrotic syndrome, malar rash and oral ul cer. SLE was discussed, however both ANA and anti-DNA antibody were pe rsistently negative. A penile ulcer was also observed. He died of acut e respiratory distress. Autopsy findings including onion skin lesion i n the spleen and haematoxylin body in the kidney resulted in the final diagnosis of SLE. To our knowledge, association of penile ulcer with SLE has not yet been reported. Therefore, the present case is thought to be extremely unusual.