CHRONIC LEG ULCERATIONS RESEMBLING VASCULITIS IN 2 SIBLINGS WITH PROLIDASE DEFICIENCY

Authors
CANTATORE FP PAPADIA F GIANNICO G SIMONETTI S CARROZZO M
Citation
Fp. Cantatore et al., CHRONIC LEG ULCERATIONS RESEMBLING VASCULITIS IN 2 SIBLINGS WITH PROLIDASE DEFICIENCY, Clinical rheumatology, 12(3), 1993, pp. 410-414
Citations number
NO
Categorie Soggetti
Rheumatology
Journal title
Clinical rheumatology → ACNP
ISSN journal
07703198
Volume
12
Issue
3
Year of publication
1993
Pages
410 - 414
Database
ISI
SICI code
0770-3198(1993)12:3<410:CLURVI>2.0.ZU;2-U
Abstract
Two cases of prolidase deficiency in two siblings are presented. The p atients complained of the typical clinical symptoms of the disease, in cluding chronic leg ulcerations resembling vasculitis. They were menta lly retarded, had typical facial characteristics, splenomegaly, and ha ematologic anomalies. Biochemical and morphological investigations con firmed the diagnosis. In these cases, alterations of the peripheral ne rvous system and decreased IgA levels were demonstrated for the first time.