T. Kanai et al., EFFICIENT PREPARATION OF ,4-THIADIAZOL-3-YL)-2-[(FLUOROMETHOXY)IMINO]ACETIC ACID, Bulletin of the Chemical Society of Japan, 66(8), 1993, pp. 2335-2338
,4-thiadiazol-3-yl)-2-[(fluoromethoxy)imino]acetic acid (2), a useful
chemical modifier of cephalosporin antibiotics, was efficiently synthe
sized from 2-[(fluoromethoxy)imino]-1,3-propanedinitrile. The stereoch
emical structure of 2 was unambiguously determined by X-ray crystallog
raphy.