This article proposes a multilevel systems model of the interactive bi
ological, psychological, and social processes in childhood illness. Th
is heuristic model can organize the investigation of pathways and mech
anisms by which these levels influence one another. A pivotal feature
of this biobehavioral family model is the construct of responsivity, w
hich is conceptualized at both family (interpersonal responsivity) and
individual (biobehavioral reactivity) levels. Individual biobehaviora
l reactivity is proposed as a bidirectional pathway by which family pa
tterns and disease processes influence one another. Illustrative clini
cal material and relevant research are presented with recommendations
for future study. This model integrates individual and family-level th
eory and thus has the capacity to bridge the fields of psychosomatics,
pediatrics, behavioral medicine, and family systems medicine.