STEREOCHEMISTRY AND PHYSIOLOGICAL SIGNIFICANCE OF HYDROXYLATION OF VITAMIN-D SIDE-CHAIN

Authors
IKEKAWA N
Citation
N. Ikekawa, STEREOCHEMISTRY AND PHYSIOLOGICAL SIGNIFICANCE OF HYDROXYLATION OF VITAMIN-D SIDE-CHAIN, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1789-1794
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1789 - 1794
Database
ISI
SICI code
0960-894X(1993)3:9<1789:SAPSOH>2.0.ZU;2-R
Abstract
Stereochemical aspect of side chain hydroxylation (C-23, C-24, and/or C-26 positions) of vitamin D3 is described. The effect of the configur ation of hydroxy group on biological activities is emphasized. Stereoc hemistry of vitamin D hydroxylation is compared with that of other nat ural hydroxylated steroids. Conformation of steroid side chain is also discussed