TOTAL SYNTHESIS OF 1-ALPHA,25,28-TRIHYDROXYERGOCALCIFEROL

Authors
BATCHO AD SERENO JF HENNESSY BM BAGGIOLINI EG USKOKOVIC MR HORST RL
Citation
Ad. Batcho et al., TOTAL SYNTHESIS OF 1-ALPHA,25,28-TRIHYDROXYERGOCALCIFEROL, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1821-1824
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1821 - 1824
Database
ISI
SICI code
0960-894X(1993)3:9<1821:TSO1>2.0.ZU;2-6
Abstract
A convergent total synthesis of 1alpha,25,28-trihydroxyergocalciferol (1), using an available A ring synthon and a CD synthon which was prep ared via a thermodynamically controlled dipolar cycloaddition of methy l 3,3-dimethylacrylate and a C-23 nitrone followed by subsequent remov al of the nitrogen function, is described.