1,25,28-TRIHYDROXYVITAMIN-D2 UP-REGULATES RENAL VITAMIN-D RECEPTOR WITHOUT CAUSING HYPERCALCEMIA

Authors
GOFF JP HORST RL USKOKOVIC M
Citation
Jp. Goff et al., 1,25,28-TRIHYDROXYVITAMIN-D2 UP-REGULATES RENAL VITAMIN-D RECEPTOR WITHOUT CAUSING HYPERCALCEMIA, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1825-1828
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1825 - 1828
Database
ISI
SICI code
0960-894X(1993)3:9<1825:1URVRW>2.0.ZU;2-U
Abstract
Treatment of rats with 1,25,28-trihydroxyvitamin D2 caused significant up-regulation in kidney vitamin D receptor in the absence of hypercal cemia. This result suggests that this relatively non-calcemic analogue (and possibly other analogues) of vitamin D may be used in stimulatin g vitamin D-regulated genetic events not associated with stimulation o f active calcium transport in vivo.