SYNTHESIS AND BIOLOGICAL EVALUATION OF 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3, 23-THIA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3 AND 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3

Authors
ALLEWAERT K VANBAELEN H BOUILLON R ZHAO XY DECLERCQ P VANDEWALLE M
Citation
K. Allewaert et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3, 23-THIA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3 AND 23-OXA-24-OXO-1-ALPHA,25-DIHYDROXYVITAMIN-D3, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1859-1862
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1859 - 1862
Database
ISI
SICI code
0960-894X(1993)3:9<1859:SABEO2>2.0.ZU;2-P
Abstract
The synthesis includes the side-chain construction starting from the I nhoffen-Lythgoe diol and coupling with the A ring. Both 23-oxa- and 23 -thia-analogues showed a decreased cell differentiating effect but eve n a more decreased calcemic effect compared with 1alpha,25-(OH)2D3.