METABOLISM AND BIOLOGICAL-ACTIVITY OF 1,25(OH)2D2 AND ITS METABOLITESIN A CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, RWLEU-4

Authors
CLARK JW REDDY GS SANTOSMOORE A WANKADIYA KF REDDY GP EIL C LASKY S TSERNG KY HORST RL USKOKOVIC MR
Citation
Jw. Clark et al., METABOLISM AND BIOLOGICAL-ACTIVITY OF 1,25(OH)2D2 AND ITS METABOLITESIN A CHRONIC MYELOGENOUS LEUKEMIA-CELL LINE, RWLEU-4, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1873-1878
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1873 - 1878
Database
ISI
SICI code
0960-894X(1993)3:9<1873:MABO1A>2.0.ZU;2-0
Abstract
We previously described the metabolism of 1,25(OH)2D2 into various sid e chain hydroxylated metabolites formed as a result of C-24, C-26 and C-28 hydroxylations in rat kidney24. We now demonstrate C-24 hydroxyla tion of 1,25(OH)2D2 in human leukemic cells and also present evidence to show that C-24 and C-26 hydroxylations either alone or in combinati on do not significantly alter the effect of 1,25(OH)2D2 on these cells , while C-28 hydroxylation reduces its activity.