METABOLISM OF 1,25(OH)2 16-ENE-D3 IN KIDNEY - INFLUENCE OF STRUCTURALMODIFICATION OF D-RING ON SIDE-CHAIN METABOLISM

Authors
REDDY GS CLARK JW TSERNG KY USKOKOVIC MR MCLANE JA
Citation
Gs. Reddy et al., METABOLISM OF 1,25(OH)2 16-ENE-D3 IN KIDNEY - INFLUENCE OF STRUCTURALMODIFICATION OF D-RING ON SIDE-CHAIN METABOLISM, Bioorganic & medicinal chemistry letters, 3(9), 1993, pp. 1879-1884
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
9
Year of publication
1993
Pages
1879 - 1884
Database
ISI
SICI code
0960-894X(1993)3:9<1879:MO11IK>2.0.ZU;2-L
Abstract
Comparative metabolism studies between 1,25(OH)2D3 and 1,25(OH)2-16-en e D3 in rat kidney indicate that both compounds are metabolized into t heir respective 24 hydroxy arid 24-oxo metabolites. While 1,25(OH)2-24 -oxo-D3 is further metabolized into 1,23,25(OH)3-24-oxo-D3 in the usua l fashion, 1,25(OH)2-24-oxo-16-ene D3 resists C-23 hydroxylation. Thus a minor change in D-ring structure appears to cause major changes in the side chain metabolism.