PATERNAL RADIATION EXPOSURE AND LEUKEMIA IN OFFSPRING - THE ONTARIO CASE-CONTROL STUDY

Objectives-To test the hypothesis that there is an association between childhood leukaemia and the occupational exposure of fathers to ionis ing radiation before a child's conception. Design-Case-control study w ith eight matched controls per case. Setting-Regions of Ontario, Canad a, with an operating nuclear facility. Subjects-Cases were children (a ge 0-14) who died from or were diagnosed as having leukaemia from 1950 to 1988 and were born to mothers living in the vicinity of an operati ng nuclear facility. Controls were identified from birth certificates, matched by date of birth and residence at birth. There were 112 cases and 890 controls. Main outcome measures-Paternal radiation exposure w as determined by a record linkage to the Canadian National Dose Regist ry. Results-Six fathers of cases and 53 fathers of controls had had a total whole body dose >0.0 mSv before the child's conception, resultin g in an odds ratio of 0.87 (95% confidence interval 0.32 to 2.34). The re was no evidence of an increased leukaemia risk in relation to any e xposure period (lifetime or six months or three months before concepti on) or exposure type (total whole body dose, external whole body dose, or tritium dose), except for radon exposure to uranium miners, which had a large odds ratio that was not significantly different from the n ull value. Conclusions-The findings of this study in Ontario did not s upport the hypothesis that childhood leukaemia is associated with the occupational exposure of fathers to ionising radiation before the chil d's conception.