CARDIOVASCULAR FEATURES IN ADOLESCENTS AND ADULTS WITH SICKLE-CELL-ANEMIA

Citation
Po. Ayuo et al., CARDIOVASCULAR FEATURES IN ADOLESCENTS AND ADULTS WITH SICKLE-CELL-ANEMIA, East African medical journal, 70(5), 1993, pp. 270-276
Citations number
29
Categorie Soggetti
Medicine, General & Internal
ISSN journal
0012835X
Volume
70
Issue
5
Year of publication
1993
Pages
270 - 276
Database
ISI
SICI code
0012-835X(1993)70:5<270:CFIAAA>2.0.ZU;2-2
Abstract
Fifty rive sickle cell anaemia (SCA) patients at the Kenyatta National Hospital were studied with a view to elucidating their cardiovascular status. Their age range was 13 to 27 years (median 18.9 years). They comprised 27 males and 28 females and their mean haemoglobin concentra tion was 8.5 +/- 1.4 g/dl. Haemoglobin level of 8.0-9.9 g/dl seen in 3 0 patients was noted to confer the lowest incidence of exertional dysp noea and palpitation. Similarly, patients with this haemoglobin level had the lowest mean heart rate. The mean blood pressure was 114.9 +/- 9.9 mmHg systolic and 64.6 +/- 10 mmHg diastolic. Blood pressures, eje ction fraction (EF) and differential fibre shortening (%D) were found to be directly related to haemoglobin level, whereas cardio-thoracic i ndex (CTI) and left ventricular dimensions were inversely related to h aemoglobin level. Mean echocardiographic measurements were within norm al limits and left ventricular functions were found to be normal in 80 .9% of the patients indicating that the majority of SCA patients at th e Kenyatta National Hospital have good cardiac function.