SPLIT HAND SPLIT FOOT DEFORMITY AND LADD SYNDROME IN A FAMILY - OVERLAP BETWEEN THE EEC AND LADD SYNDROMES

A mother and daughter are reported with apparently dissimilar syndrome s. The mother has a split hand/split foot deformity and the daughter a condition consistent with a diagnosis of LADD syndrome. Absence of cl efting and deficient formation of saliva and tears are the main signs that differentiate the LADD from the EEC syndrome. However, no distinc t feature is constant between these two autosomal dominant disorders t hat show great phenotypic variability. This report emphasises the over lap between the LADD and the EEC syndromes.