CHANGES IN PLASMA COPPER AND ZINC DURING RAT DEVELOPMENT

Authors
LISTA EM SOLE J AROLA L MAS A
Citation
Em. Lista et al., CHANGES IN PLASMA COPPER AND ZINC DURING RAT DEVELOPMENT, Biology of the neonate, 64(1), 1993, pp. 47-52
Citations number
23
Categorie Soggetti
Pediatrics
Journal title
Biology of the neonate → ACNP
ISSN journal
00063126
Volume
64
Issue
1
Year of publication
1993
Pages
47 - 52
Database
ISI
SICI code
0006-3126(1993)64:1<47:CIPCAZ>2.0.ZU;2-3
Abstract
The association of copper and zinc to plasma ligands was studied durin g the rat perinatal period. Analysis was carried out by means of colum n chromatography (Sephadex G-150) and atomic absorption spectrophotome try. Levels of copper were low at birth and showed a sharp increase af ter day 10. This increase was similar to that of ceruloplasmin activit y as well as its association with copper. Zinc levels, instead, showed higher levels before birth and decreased slowly toward the adult valu es. Association of zinc to albumin and associated proteins showed a pa ttern similar to the decrease in plasma zinc levels.