PARLODEL(R) IN EARLY COMBINATION WITH LEV ODOPA IN PARKINSONS-DISEASE- COMPARISON OF 2 TITRATIONS

In order to compare two titrations of Parlodel(R) in early combination with levodopa in the treatment of Parkinson's disease a multicentre r andomized open study was performed with a fast titration in group A (1 5 mg/day for 3 weeks) and slow in group B (15 mg/day for 5 weeks). 153 patients were included : 77 in group A and 76 in group B. The recomme nded titration was observed in 76 % in group A and 88 % in group B, th e difference was not significant. The efficacy assessed by the Webster Scale was remarkable and similar in the two groups. This study confir ms the additive benefit of bromocriptine on the symptoms and long term complications of levodopa therapy, but no absolute conclusion can be drawn regarding the best titration.