CHEMISTRY OF HYODEOXYCHOLIC ACID .8. STER EOSELECTIVE SYNTHESIS OF (24R,25R)-24,25,26-TRIHYDROXYCHOLESTEROL BY USING OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION OF OLEFIN

Authors
RUAN BF WANG ZQ
Citation
Bf. Ruan et Zq. Wang, CHEMISTRY OF HYODEOXYCHOLIC ACID .8. STER EOSELECTIVE SYNTHESIS OF (24R,25R)-24,25,26-TRIHYDROXYCHOLESTEROL BY USING OSMIUM-CATALYZED ASYMMETRIC DIHYDROXYLATION OF OLEFIN, Huaxue xuebao, 51(6), 1993, pp. 612-618
Citations number
5
Categorie Soggetti
Chemistry
Journal title
Huaxue xuebao → ACNP
ISSN journal
05677351
Volume
51
Issue
6
Year of publication
1993
Pages
612 - 618
Database
ISI
SICI code
0567-7351(1993)51:6<612:COHA.S>2.0.ZU;2-N
Abstract
This paper reports a stereoselective synthesis of (24R, 25R)-24, 25, 2 6-trihydroxycholesterol 10, which is important intermediate for synthe sis of Vitamin D3 analog, through seven steps from 1. The key step is Osmium-Catalyzed asymmetric dihydroxylation of compound 2. The total y ield is 40%.