AN IDENTICAL TWIN PAIR DISCORDANT FOR RHEUMATOID-ARTHRITIS AND ANKYLOSING-SPONDYLITIS

Authors
MACGREGOR AJ FOX H OLLIER WER SNAITH ML SILMAN AJ
Citation
Aj. Macgregor et al., AN IDENTICAL TWIN PAIR DISCORDANT FOR RHEUMATOID-ARTHRITIS AND ANKYLOSING-SPONDYLITIS, Clinical and experimental rheumatology, 11(4), 1993, pp. 425-428
Citations number
26
Categorie Soggetti
Rheumatology
Journal title
Clinical and experimental rheumatology → ACNP
ISSN journal
0392856X
Volume
11
Issue
4
Year of publication
1993
Pages
425 - 428
Database
ISI
SICI code
0392-856X(1993)11:4<425:AITPDF>2.0.ZU;2-#
Abstract
Both rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have an increased familial occurrence and each disease is associated with the inheritance of specific HLA antigens. We report a pair of identical t win brothers with discordant disease phenotypes: one developed AS at t he age of 26, and the other developed RA at the age of 55. The twins p ossessed both of the disease susceptibility antigens HLA B27 and DR4. Differences in the twins' environmental exposure are discussed.